Abstract
This study was undertaken to determine vitamins A, D and E composition of aqueous and ethanolic extracts of Trema guineensis and effect of supplementation of these extracts on serum concentrations of these vitamins. Aqueous and ethanolic extracts of Trema guineensis were obtained by decoction and maceration of leaves powder, respectively. Then, they were administered to animals at doses of 100 and 200 mg/kg body weight against a control group treated with distilled water for two weeks. Composition of vitamins in extracts and serum concentrations of vitamins A, D and E were performed by HPLC. Results showed that Trema guineensis extracts contained high concentrations of vitamins A, D and E. Thus, vitamins A and D serum concentrations were weakly influenced while that of vitamin E increased strongly during administration of Trema guineensis extracts. This study therefore showed that extracts of Trema guineensis had vitamins A, D and E and a beneficial effect on serum concentrations of these vitamins.
Highlights
Results revealed that vitamins A, D and E were present in aqueous and ethanolic extracts of Trema guineensis leaves but in variable amounts
At day 0 (D0) there was no significant difference in vitamins concentrations between all groups
Administration of aqueous and ethanolic extracts of Trema guineensis to doses of 100 and 200 mg/kg body weight resulted in a non-significant increase in serum levels of vitamins A and D on day 7 (D7) in comparison to control group
Summary
Vitamins are organic compounds essential to life. They are generally obtained in very small quantities by food and provide various biological functions [1]. Vitamins A, D and E constitute the class of fat-soluble vitamins [2]. Vitamin A refers to a group of compounds essential for vision, growth, cellular differentiation and proliferation, reproduction and immune system integrity [3]. It has antioxidant properties [4]. Vitamin D plays a central role in
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