Concentrations of ampicillin and cefadroxil in human serum and mixed saliva following a single oral administration of talampicillin and cefadroxil, and relationships between serum and mixed saliva concentrations

Abstract

1. 1. The concentrations of ampicillin (ABPC) from talampicillin (TAPC) and cefadroxil (CDX) in serum and mixed saliva were assayed by the thin layer disc plate method. 2. 2. Talampicillin and cefadroxil (500 mg) were given by a single oral administration. 3. 3. The relationships between serum and mixed saliva ampicillin and cefadroxil concentrations were evaluated in the paired specimens collected from 10 different persons, respectively. 4. 4. The means of concentration ratios of mixed saliva to serum ampicillin and cefadroxil were 0.006 ± 0.003 and 0.025 ± 0.010 (mean ± SD), respectively. 5. 5. Significant correlation coefficients between mixed saliva and serum concentrations were found for both ampicillin and cefadroxil, which were r = 0.78, P < 0.001, and r = 0.67, P < 0.001, respectively.