Abstract
ABSTRACT The concentrations of unconjugated estrone (E1), estradiol (E2), testosterone (T), androstenedione (A) and progesterone (P) were measured in peripheral and ovarian venous plasma collected from 18 healthy women on days 7–30 of the menstrual cycle at the time of elective tubal ligation. An additional 4 steroids, pregnenolone, 17α-hydroxyprogesterone (17-OHP), 20α-dihydroxyprogesterone (20-OHP) and dehydroepiandrosterone (DHEA), were measured in ovarian venous plasma. In 2 subjects, one in the follicular phase and one in the luteal phase, blood was obtained from both ovaries. There was evidence of secretion by the ovary of all the steroids measured. Of the C18 and C19 steroids, E2 and A, respectively, were secreted by the ovary in largest amounts. There was a wide range of concentration of each steroid in ovarian venous plasma collected at the same time of the cycle from different subjects. High concentrations of E2 were associated with high levels of E1, T and A. DHEA appeared to be higher in plasm...
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