Abstract
Objectives to evaluate the association between essential chemical element levels in whole blood and in pathologic mucosa and chronic rhinosinusitis severity in children.
 Material and methods. A total of 154 children aged from 6 to 17 years were examined. Among them, 88 children had chronic rhinosinusitis (CRS) and underwent functional endoscopic sinus surgery (FESS). The 66 healthy children were included in the control group. Life quality was assessed using SNOT-20 (Sino-Nasal Outcome Test-20). Endoscopic and computer tomography findings were evaluated using Lund Kennedy and Lund Mackay scales, respectively. The assessment of essential element levels in whole blood samples was performed using inductively-coupled plasma mass-spectrometry.
 Results. The obtained data demonstrate that total SNOT-20 scores in CRS patients were 68% higher than in controls. At the same time, whole blood calcium, selenium, zinc, and magnesium levels were 6%, 28%, 20%, and 3% lower than the respective control values. The analysis of pathologic mucosa demonstrated that the chemical element contents were reducing in the following order: Ca Mg = Fe Zn Cu Mn Se. However, only whole blood selenium level correlated significantly with its tissue level. In multiple regression models, the whole blood Se level was inversely associated with SNOT-20 and Lund Mackay total scores.
 Conclusion. Therefore, the obtained data allow to propose the potential role of altered calcium, magnesium, zinc and selenium metabolism in CRS progression.
Highlights
Хронический риносинусит (ХРС) представляет собой воспалительное заболевание полости носа и околоносовых пазух
The obtained data allow to propose the potential role of altered calcium, magnesium, zinc and selenium metabolism in chronic rhinosinusitis (CRS) progression
В патогенезе ХРС важную роль играют иммунный дисбаланс, нарушения мукоцилиарного клиренса, барьерной функции эпителия, а также особенности взаимодействия с микробными патогенами [1]
Summary
Цель – изучение взаимосвязи концентрации эссенциальных химических элементов в цельной крови с их содержанием в образцах патологически измененной слизистой оболочки околоносовых пазух и тяжестью хронического риносинусита у детей. В то же время концентрация кальция, селена, цинка и магния в цельной крови пациентов была ниже таковой в группе здоровых обследуемых на 6%, 28%, 20% и 3% соответственно. Результаты настоящего исследования свидетельствуют о возможной роли нарушений обмена кальция, магния, цинка и селена в развитии и прогрессировании хронического риносинусита. Для цитирования: Алексеенко С.И., Дворянчиков В.В., Скальный А.В., Аникин И.А., Исаченко В.С., Тиньков А.А. Взаимосвязь концентрации эссенциальных химических элементов в цельной крови и слизистой оболочке околоносовых пазух c тяжестью хронического риносинусита у детей.
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