Abstract
NEITHER the precise mechanism of amino-acid transport in muscle nor the means of its regulation is known. In most instances (there are exceptions1,2) what has been examined is the ratio of radioactivity in the tissue water to that in the medium after incubating muscle with a single radioactive amino-acid. There is no assurance that this accurately reflects the concentration ratio for the unlabelled amino-acid. Moreover, these experiments are of the nature of black-box investigations since the concentration of individual amino-acids in rat diaphragm and heart muscle, the two tissues most frequently used for in vitro examination, has only infrequently been reported3. Clearly, what is required of a proper examination of the mechanism, and the hormonal regulation, of amino-acid penetration into muscle is a chemical determination of the exact amount of amino-acids in tissue and medium. Preparatory to such an investigation we have determined the concentration of ninhydrin reacting material in rat diaphragm and heart muscle and in rat plasma.
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