Concentraciones plasmáticas del factor de crecimiento vascular endotelial total en preeclampsia y eclampsia

Abstract

ObjectiveTo compare plasma concentrations of total vascular endothelial growth factor in eclamptic, preeclamptic and normotensive pregnant women. Materials and methodWe included 30 patients with mild preeclampsia (group A), 30 patients with severe preeclampsia (group B) and 30 patients with eclampsia (groupC). A control group with a similar age and body mass index to the study groups was selected, consisting of 30 healthy pregnant women (group D). Only nulliparous patients were selected. Plasma samples were collected in all patients before delivery and in the study groups immediately after diagnosis for plasma total vascular endothelial growth factor determination. ResultsValues of total vascular endothelial growth factor were higher in severe preeclamptic patients (141.5± 48.4ng/ml) and in patients with eclampsia patients (141.4±37.9ng/ml). Values were lower in mild preeclamptic patients (62.8±22.8ng/ml). Values of total vascular endothelial growth factor were higher in the study groups than in controls (22.1±3.99ng/ml; P<.05). Linear regression analysis showed that the factors significantly related to plasma total vascular endothelial growth factor concentrations were 24-hour proteinuria, uric acid, transaminases and creatinine (P<.05). ConclusionThe results of this study show that eclamptic and preeclamptic patients had higher plasma total vascular endothelial growth factor concentrations than normotensive pregnant women without these complications.