Concentraciones de lípidos y lipoproteínas en menopáusicas tratadas con raloxifeno

Abstract

Objective To determine cholesterol, triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) concentrations in postmenopausal women treated with raloxifene after 3 months of treatment. Methods Forty-five postmenopausal women were treated with 60 mg/day of oral raloxifene for 3 months. Cholesterol, triglyceride, LDL, and HDL concentrations were assessed. Results The mean age of the postmenopausal women was 49.3±3.9 years and the mean body mass index was 28.1±3.7 Kg/m2. Follicle-stimulating hormone and estradiol concentrations were 91.7±11.6 UI/ml and 20.1±11.8 pg/ml, respectively. Cholesterol (231.3±36.8 mg/dl at baseline and 216.5±21.3 mg/dl after 3 months) and LDL concentrations (154.6±11.2 mg/dl at baseline and 138.9±14.6 mg/dl after 3 months) were significantly reduced (6% and 10%, respectively) after 3 months of raloxifene use (p<0.05). There were no significant variations in triglycerides or HDL concentrations after raloxifene use (p=ns). Conclusion Raloxifene use in postmenopausal women significantly reduces cholesterol and LDL concentrations without modifying triglyceride and LDL concentrations after 3 months of treatment.