Abstract
Chromatin is a long polymer made of DNA and proteins; its four-dimensional (spatial and temporal) organisation is crucial in regulating cellular processes like transcription, replication and DNA repair. How the chromatin self-organises spatially and temporally is a question of active research. In this thesis, we discuss computational studies to predict the 3D organisation of chromatin, given experimentally measured contact probability (3C, 5C and Hi-C) data. We have developed an inverse Brownian dynamics method that can compute the chromatin organisation. We also investigate the dynamics of chromatin on the length scale of a domain.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
