Computing the Projected Reachable Set of Stochastic Biochemical Reaction Networks Modeled by Switched Affine Systems

Abstract

A fundamental question in systems biology is what combinations of mean and variance of the species present in a stochastic biochemical reaction network are attainable by perturbing the system with an external signal. To address this question, we show that the moments evolution in any generic network can be either approximated or, under suitable assumptions, computed exactly as the solution of a switched affine system. We then propose a new method to approximate the reachable set of such a switched affine system. A remarkable feature of our approach is that it allows one to easily compute projections of the reachable set for pairs of moments of interest, without requiring the computation of the full reachable set, which can be prohibitive for large networks. As a second contribution, we also show how to select the external signal in order to maximize the probability of reaching a target set. To illustrate the method, we study a renowned model of the controlled gene expression and we derive estimates of the reachable set, for the protein mean and variance, that are more accurate than those available in the literature and consistent with experimental data.