Abstract
A key goal of the DOE office of science's systems biology program, genomes to life (GTL), is to achieve, over the next 10 to 20 years, a basic understanding of thousands of environmental microbes and microbial systems in their native environments. This goal demands that we develop new models for scientific discovery that integrate methods and systems which tightly couple advanced computing, mathematics, algorithms, and data-management technologies with large-scale experimental data generation.
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