Abstract
11584Background: Tumor infiltrating lymphocytes (TILs) are a part of the dynamic immune microenvironment. Clinical trials with immune checkpoint inhibitors report significant increase in TILs in responders in follow up tumor biopsies. Monitoring TILs on treatment using radiomic features extracted from routine follow up computed tomographic (CT) images can be a non-invasive surrogate to biopsy to detect early response. We conducted a proof of concept study to find out if radiomic features extracted from CT images can identify patients with high and low TILs in non-small cell lung cancer (NSCLC). Methods: A cohort of 50 consecutive patients who underwent lobectomy for early stage NSCLC were identified and TIL were characterized using routine hematoxylin and eosin (H&Es) slides. TILs were quantified on a previously reported scale of 0 to 3 based on intensity of TIL. Of the 50 cases 17 outliers who had high TILs (3+) or low TILs (0) were identified. The study team was provided with CT images from 4 patients w...
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