Computer-Aided Differentiation for Pathology Images

Abstract

The evolution of whole slide imaging (WSI) technology promotes the pathology environment based on digital imaging, called “digital pathology,” and enables monitor-based diagnosis instead of conventional diagnosis based on microscopic observation, as well as the application of computer image analysis to pathology practice. This chapter introduces the background, basic techniques, and examples of image analysis technology for digital pathology. Computer-aided diagnosis with quantifying morphological and molecular features will be a significant tool for diagnostic pathology such as cancer detection, grade differentiation, and the decision of therapeutic plan. Some systems for automated processing of WSI data are also presented including the systems that have been employed in practice. The color correction, which is one of the most important issues in the pathological image analysis, is also addressed.