Abstract
This study aims to investigate the manifestation of CT, MRI and dynamic enhanced scans for primary hepatic neuroendocrine cell carcinoma. CT or MRI arterial and venous phase scan images of 19 cases of pathologically confirmed PHNEC were retrospectively analyzed. 14 cases (73.68%) with single lesion, 5 cases (26.3%) with multiple lesions, with an average diameter of 13.2 cm. Some 12 cases (63.16%) showed inhomogeneous enhancement, seven cases (36.8%) showed homogeneous enhancement, 13 cases (68.4%) demonstrated significant enhancement in the arterial phase, 13 cases (68.4%) had significantly enhanced portal venous phase including 7 cases (36.8 %) with portal venous phase density or signal above the arterial phase and 5 cases (26.3%) with the portal vein density or signal below the arterial phase. Seven cases (36.8%) had continued strengthened separate shadows in the center of the lesion. Thrombosis were not seen in portal veins. CT and MRI images of liver cell neuroendocrine carcinoma have certain characteristics that can provide valuable information for diagnosis and differential diagnosis.
Highlights
Neuroendocrine carcinoma was known as carcinoid or addicted silver cell carcinoma, often occurred in the gastrointestinal tract
Aim: This study aims to investigate the manifestation of CT, MRI and dynamic enhanced scans for primary hepatic neuroendocrine cell carcinoma
Less domestic and foreign reports on Primarily hepatic neuroendocrine carcinoma (PHNEC) was available, as well as little understanding of its origin (Pilichowska et al, 1999; Solcia et al, 2000; Yao et al, 2008), three assumptions were proposed currently: 1) tumor cells derived from intrahepatic biliary epithelial neuroendocrine cells. 2) tumor tissue derived from the liver ectopic pancreas or adrenal tissues. 3) tumor cells derived from the liver pluripotent stem cells
Summary
Neuroendocrine carcinoma was known as carcinoid or addicted silver cell carcinoma, often occurred in the gastrointestinal tract. Hepatic neuroendocrine carcinoma (PHNEC) was very rare, accounting for 1-5% of primary liver tumors, and 0.8%-4.0% of systemic neuroendocrine tumors (Pilichowska et al, 1999; Solcia et al, 2000; Yao et al, 2008; Huang et al, 2010). Both the clinical symptoms and imaging findings were not specific, resulting in difficult for preoperative diagnosis. Data of 19 cases with complete preoperative imaging data were analyzed retrospectively, and surgical resection or biopsy of the primary hepatic neuroendocrine carcinoma were performed to explore the performance characteristics of CT and MRI imaging for PHNEC in order to improve the level of image diagnosis and differential diagnosis for PHNEC
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