Abstract
A computer simulation program was used to compare various techniques the assay of thyroid function to see which most closely reflected changes in the secretion rate of the thyroid hormone. The rate of radioiodine release from the thyroid gland was the most sensitive and least confounded by other parameters of iodine metabolism. Blood protein-bound iodine should closely parallel the thyroixine secretion rate, but it is subject to interference from the dietary level of stable iodine. The uptake of radioiodine by the thyroid gland was confounded by many nonthyroidal parameters, primarily excretion. Simulation of the rate of disappearance of injected radiothyroxine indicated that it is a sensitive indicator of thyroid function only if hormone excretion is constant.
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