Abstract
The ionized states of molecular analytes located on solid surfaces require profound investigation and better understanding for applications in the basic sciences in general, and in the design of nanobiosensors, in particular. Such ionized states are induced by the interactions of molecules between them in the analyzed substance and with the target surface. Here, computer simulations using COMSOL Multiphysics software show the effect of surface charge density and distribution on the output generation in a dynamic PIN diode with gate control. This device, having built-in potential barriers, has a unique internal integration of output signal generation. The identified interactions showed the possibility of a new design for implementing a nanobiosensor based on a dynamic PIN diode in a mode with surface charge control.
Highlights
Methods and technology for the sensitive detection, characterization, and monitoring of biomolecules and other biochemical and biophysical analytes are urgently needed in the life sciences, clinical diagnostics, the pharmaceutical sciences, the engineering of substances and materials, environmental research, and food control [1,2,3,4,5,6].Nanobiosensors are analytical devices that combine a biologically sensitive element with a nanostructured transducer, and are widely used for molecular detection
Computer simulations using COMSOL Multiphysics software show the effect of surface charge density and distribution on the output generation in a dynamic PIN diode with gate control
The identified interactions showed the possibility of a new design for implementing a nanobiosensor based on a dynamic PIN diode in a mode with surface charge control
Summary
Methods and technology for the sensitive detection, characterization, and monitoring of biomolecules (proteins, lipids, DNA, and RNA molecules) and other biochemical and biophysical analytes are urgently needed in the life sciences, clinical diagnostics, the pharmaceutical sciences, the engineering of substances and materials, environmental research, and food control [1,2,3,4,5,6]. Nanobiosensors are analytical devices that combine a biologically sensitive element with a nanostructured transducer, and are widely used for molecular detection. A semiconductor device based on the field effect makes it possible to detect variations in the charges of biological processes in real-time and in a non-invasive way. In such devices, one positive or one negative charge of a molecule electrostatically interacts with one electron charge in a semiconductor device. In a dynamical anode voltage regime, an output analog signal is proportional to the energy dose of an incident electromagnetic wave (visible light) This phenomenon includes photo- and thermo-generation of electron-hole pairs in the semiconductor bulk, and gate control of potential barrier magnitude, which, in turn, could regulate the charge carrier flow. The obtained results show some principal possibilities of using this device as a highly sensitive semiconductor nanobiosensor which performs signal integration, controlled by surface charge
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