Abstract
Tryptophan metabolism via the kynurenine pathway has been studied through the simulation of a model system on an analog computer. Experiments pertaining to the coenzyme effect of pyridoxal on metabolite distribution were performed under a variety of conditions. The effects of regulatory feedback on some enzyme activities and metabolite concentrations were explored. Tryptophan-load experiments were performed. The conclusion is drawn that model systems established on currently available information on tryptophan metabolism in liver are not adequate to interpret various abnormal distribution patterns of metabolites under conditions of disease. Also, current clinical measurements on a variety of metabolic intermediates do not yield significant information on the mechanism of disease.
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