Abstract
A computer model of the stem cell population is presented. Proliferation control is achieved solely in this model by a feedback, which changes the flow of cells from the g0 state into the g1 phase according to the amount of the DNA synthesizing S phase cells. Behavior of the model was compared with experimental data available about the CFUs (colony-forming units — spleen) cell population. A reasonable agreement between simulation results and experimental data could be obtained provided that some cells do not pass through the G0 state during their cell cycle. Necessity to establish the seeding efficiency of the spleen colony technique arose when experimental CFUs data showing pluripotential stem cells response to hydroxyurea damage were compared with results obtained from the model.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
