Computer chemistry of non-peptide oxytocin agonists.

Abstract

Oxytocin is a 9-amino acid peptide that is neurosecreted from the paraventricular nucleus of the hypothalamus and the supraoptic nucleus and enters the blood from the posterior lobe of the pituitary gland. Peripheral effects are smooth muscle contraction and lactation. One kind of oxytocin receptor is Gq of 7-transmembrane G protein. There are three types of Vasopressin, V1, V2, and V3, V1 and V3 are G protein phosphorylated inositol / Ca systems, and V2 is a cAMP system.