Abstract
Hirsutism is a condition of unwanted, male-pattern terminal hair growth in women. Electro epilation, laser treatment, intense pulsed light therapy, eflornithine cream, and oral antiandrogen medications are the various allopathic therapeutics have been employed for treatment of Hirsutism. However, a significant number of patients experience discomfort with reported procedures. Cyperus Rotundus Linn. have reported for its anti-androgenic activity effective against Hirsutism disorder. The main objective of present investigation is to screen the selected phytoconstituents of stated plant against 5 α Reductase Enzyme. In this study Cyperene, humulen, β- selinene, campholenic aldehyde, and α-pinene were docked with 5 α Reductase Enzyme using PyRx 0.8.Autodock and binding energies were obtained. The present investigation concludes that the molecular docking analysis of selected phytoconstituents with 5 α reductase enzyme shows good interaction. The binding affinity of Humulen is higher than others whereas campholenic aldehyde showed lowest affinity amongst all other constituents. Further studies need to be performed at laboratory level to support results of computational screening of present investigation.
Highlights
Androgen hormone is the one whose presence determines the growth of sexual hair
After puberty due to increase in the levels of androgen, vellus follicles in specific areas develop into terminal hairs and become sexual hair follicles [1,2,3]
Determining binding affinities or interaction studies of different ligands from natural and synthetic source with Molecular Docking that of biological targets. This promoted us to carry out Molecular Docking was performed using PyRx present research work to study the selected 0.8.Autodock preferences were obtainedafter the phytoconstituents from the plant source of Cyperus completion of docking, for both ligand and target in Roduntus Linn against 5α reductase enzyme which may PDBQT format
Summary
Androgen hormone is the one whose presence determines the growth of sexual hair (androgenic hair). Hirsutism condition results from interaction between the androgen level and the hair follicles which are sensitivity to androgen [4]. Androgen group of hormones are activated on target cells by two kinds of proteins: the androgen receptor and the 5α-reductase enzyme. Possessed anti-androgenic activity effective against In current study beta selinene, campholenic Aldehyde, Hirsutism disorder.
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