Computer‐assisted retention prediction system in reversed‐phase HPLC for O‐ethyl O‐aryl N‐isopropyl phosphoramidothioates

Abstract

AbstractA computer‐assisted retention prediction system (RPS) of fifteen O‐ethyl O‐aryl N‐isopropyl phosphoramidothioates (1) in reversed‐phase HPLC was investigated. The system is based on the use of four physicochemical parameters (hydrophobicity II, electric effect σ, field effect F and steric effect Es) which is closely related to the retention mechanism in reversed‐phase HPLC. The system was evaluated by comparing the measured retention data with the predicted ones. The predicted values were consistent with the measured values within a relative error of 11.5%.