Abstract
A simple, accurate and fast method for the determination of promethazine, chlorpromazine and trimeprazine neuroleptics in drug formulations by flow injection spectrophotometric detection was developed. The method was based on the oxidation of the drug with potassium dichromate in sulphuric acid media. Optimum conditions were obtained by using the modified simplex computer programme. A 110-μl sample volume was taken as reasonable for all the compounds. The optimum conditions reached were 76-cm coil length, 6.00 ml/min flow rate, 3.10 M sulphuric acid and 0.00167 M dichromate for promethazine; 94-cm coil length, 5.00 ml/min flow rate, 1.48 M sulphuric acid and 0.00185 M dichromate for chlorpromethazine and 80-cm coil length, 6.00 ml/min flow rate, 3.44 M sulphuric acid and 0.000500 M dichromate for trimeprazine. High sample throughput of at least 200 samples per hour was obtained for all compounds. Acceptable relative standard deviations in the range ±0.4–0.9%, and good accuracy in the range 99.5–99.9% were attained when the method was statistically compared with the BP method and when applied to proprietary drugs, without suffering interferences.
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