Computed Tomography Imaging Agent Based on Gold Nanoparticles for Internal Iliac Artery Embolization after Endovascular Abdominal Aortic Repair and CCN3 Protection Mechanism

Siying Pei,Hanrui Wang,Shuhua Deng,Dongxu Fan,Haoran Mei,Yao Sun,Songwen Tan

doi:10.1155/2021/6453888

Abstract

Abdominal aortic aneurysm is more stressful and has more complications in many diseases. During treatment and repair, arteriosclerosis, abdominal congestion deposition, and abdominal swelling cannot be eliminated. In this paper, we used the seed growth method to obtain gold nanoparticles (AuNPs) with good morphology and dispersion. The AuNPs of larger aspect ratio synthesized in this experiment moved their longitudinal plasmon resonance absorption peak to the near-infrared region, which provided suitable materials for subsequent experiments and laid the foundation for the photothermal therapy of tumors. Experiments show that near-infrared rays can penetrate into deep tissues to overcome the shortcomings that visible light cannot penetrate abdominal aorta well. AuNPs absorb near-infrared rays, thereby generating heat energy to achieve the purpose of treating tumors. In addition, AuNPs also have fluorescent properties, combined with other forms of imaging methods, to achieve the purpose of multimodal imaging, and improve the diagnostic accuracy of studying the protection mechanism of the nephroblastoma overexpressed (NOV or CCN3) gene.

Highlights

Abdominal aortic aneurysm (AAA) is defined as a permanent local expansion of the abdominal aorta exceeding 3.0 cm or a diameter exceeding 1.5 times the normal diameter [1], which is a common clinical disease in vascular surgery
We considered that the relief of pelvic ischemic symptoms in these 4 patients is related to the eventual establishment of collateral circulation and considered transient gluteal muscle ischemia, so these 4 patients were included in this study
Comparing with other patients without gluteal muscle claudication in the bilateral internal iliac embolism group, no significant difference was found in commodity trading advisors (CTA) images before and after surgery

Summary

Introduction

Abdominal aortic aneurysm (AAA) is defined as a permanent local expansion of the abdominal aorta exceeding 3.0 cm or a diameter exceeding 1.5 times the normal diameter [1], which is a common clinical disease in vascular surgery. The development of multifunctional, high-sensitivity, and high-specificity contrast agents is an effective measure to improve the accuracy of early diagnosis of tumors, and it is the current development trend of nanomedicine and imaging diagnostics. The contrast agents currently used in the clinic are mainly small molecular compounds based on iodine (such as iohexol). The contrast ratio of gold per unit mass is better than that of iodine, and the modified AuNPs have a longer imaging time and better imaging effect before and after entering the organism [11]. The targeting and long circulation of gold nanoprobes can be achieved, which can be precise It shows the tumor morphology, location, and size, with high sensitivity, which can improve the ability of tumor identification and diagnosis. AuNPs have fluorescent properties, combined with other forms of imaging methods, to achieve the purpose of multimodal imaging, and improve the diagnostic accuracy of studying the protection mechanism of CCN3

Materials and Methods

Results

Without Au nanoparticles

Discussion