Computed tomographic features of pregnant women with pandemic H1N1 virus infection

Abstract

ObjectiveThe aim of this study was to review the chest CT findings at presentation and on follow-up in pregnant women with confirmed S-OIV. Materials and methodsWe reviewed the CT findings at presentation (n = 16) and after hospital admission (n = 10) of 18 pregnant women diagnosed with Influenza A (H1N1) in our hospital between Nov 5, 2009 to Dec 12, 2009. CT manifestations were reviewed independently by 3 observers who reached a consensus decision. Chest CT findings were analyzed with regard to the patterns and distributions of pulmonary abnormalities. ResultsThe predominant CT findings at presentation consisted of unilateral (n = 6) or bilateral (n = 10) ground-glass opacities or focal unilateral (n = 3) or bilateral (n = 9) areas of consolidation. 4 of the 16 patients had associated mild thickening of the interlobular septa. The predominant follow-up abnormalities consisted of unilateral (n = 3) or bilateral (n = 7) ground-glass opacities or unilateral (n = 1) or bilateral (n = 1) consolidation. 8 of the 10 patients had interstitial opacity findings, including smooth thickening of the interlobular septa (n = 5), reticulation (n = 2) and honeycombing (n = 1). 3 patients had irregular lines (n = 3) and traction bronchiectasis (n = 1). ConclusionThe most common CT manifestations of pregnant women with confirmed S-OIV are unilateral or bilateral ground-glass opacities or focal unilateral or bilateral areas of consolidation. In pregnant women, the abnormalities seem to more extensive than general patients. Some pregnant women patients may develop interstitial opacity and traction bronchiectasis due to fibrosis.