Abstract
Chromatography with random packing is one of the most widely used methods for separation and analysis. The pore connectivity and pore size distribution of structured packed beds would be designed to improve column separation performance. We have investigated the separation performance of different ordered packings in detail with the volume averaging method and numerical simulations, including the simple cubic (SC), body center cubic (BCC), and face center cubic (FCC) packing with different particles. With the same particle shape, the FCC packing form is better for separation performance. Compared to the corresponding configurations with spherical particles, the plate height of long ellipsoidal particle models is remarkably reduced in the SC and BCC packing. However, the FCC-L packing doesn’t obtain lower reduced plate height. The results of the BCC-L, FCC-S and FCC-L packing are close. These results provide more detailed flow characteristics and mass transfer process in ordered packed beds, which is meaningful for the optimum design.
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