Abstract
Objective: The study aims to design Proline derivatives having anti-hypertensive activity by computational molecular modelling. Methods: Various methodology used in the study include lead identification, selecting derivatives, molecular modelling, target identification, docking and visualizing the output. The ligands that show good binding scores are selected and Captopril was selected as standard drug. Results: In this study, we designed various derivatives of acylated proline into a ligand having ACE Inhibitor activity. All the twenty designed derivatives showed more binding affinity towards the receptor compared to the standard drug Captopril. Conclusions: The work concluded that the designed twenty ligands are promising ACE Inhibitors which provides anti-hypertensive activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Open Access Research Journal of Science and Technology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
