Abstract
Cell migration is a fundamental cell biological phenomenon that underlies many physiological processes. To migrate, cells must polarize, sense a direction, and deploy a motile mechanical machinery. Computational modeling of simple motile fish keratocyte cells was an integral part of understanding general mechanochemical mechanisms of these three aspects of cell migration. I will demonstrate how a combination of data analysis and detailed mechanistic modeling elucidated mechanics of self-polarization, steady migration and turning of single keratocytes. I will then describe data on directional migration of individual cells and cohesive groups of cells in an electric field and show that a simple conceptual model sheds light on surprising properties of the directional sensing in collective cell migration.
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