Computational modeling of thrombotic microparticle deposition in nonparallel flow regimes.

Abstract

Thrombotic microparticles (MPs) released from cells and platelets in response to various stimuli are present in elevated numbers in various disease states that increase the risk for thrombotic events. In order to understand how particles of this size may localize in nonparallel flow regimes and increase thrombotic risk, a computational analysis of flow and MP deposition was performed for 3 deg of stenosis at moderate Reynolds number (20<Re<80) and for recirculation zones at low Reynolds (1) number. The results indicate that MP deposition results primarily from impaction and not by diffusive flux.