Abstract
A computational model of drug dissolution in the human stomach is developed to investigate the interaction between gastric flow and orally administrated drug in the form of a solid tablet. The stomach model is derived from the anatomical imaging data and the motion and dissolution of the drug in the stomach are modeled via fluid-structure interaction combined with mass transport simulations. The effects of gastric motility and the associated fluid dynamics on the dissolution characteristics are investigated. Two different pill densities are considered to study the effects of the gastric flow as well as the gravitational force on the motion of the pill. The average mass transfer coefficient and the spatial distributions of the dissolved drug concentration are analyzed in detail. The results show that the retropulsive jet and recirculating flow in the antrum generated by the antral contraction wave play an important role in the motion of the pill as well as the transport and mixing of the dissolved drug concentration. It is also found that the gastric flow can increase the dissolution mass flux, especially when there is substantial relative motion between the gastric flow and the pill.
Highlights
The oral route is used most frequently for drug administration in humans due to its safety, reduced cost, and high degree of patient compliance, but it is the most complex way for an active pharmaceutical ingredient (API) to enter the body. This complexity is because drug absorption via the gastrointestinal (GI) tract depends on factors related to the drug and its formulation, and on the contents of the stomach and stomach motility and the associated fluid dynamics
The present study focuses on the initial dissolution of a non-disintegrating pill to investigate the effects of gastric motility and associated fluid dynamics on the dissolution characteristics
One can see the energetic flows consist of jet and recirculation in the antrum region, while the flows in the body and fundus are very weak. This is because the gastric flow is primarily driven by the antral contraction wave
Summary
The oral route is used most frequently for drug administration in humans due to its safety, reduced cost, and high degree of patient compliance, but it is the most complex way for an active pharmaceutical ingredient (API) to enter the body This complexity is because drug absorption via the gastrointestinal (GI) tract depends on factors related to the drug and its formulation, and on the contents of the stomach and stomach motility and the associated fluid dynamics. Drug Dissolution in the Stomach at the cost of increasing device complexity Despite this increased complexity, these in-vitro simulators are still unable to adequately recreate biorelevant conditions of gastric motility-induced fluid flow, mixing, shear and pressure forces, and the biochemical status associated with food contents and gastric secretions (Gao, 2017; Butler et al, 2019). The correlation between the fluid shear force on the pill and the surface diffusion rate is examined to study the effect of gastric fluid flow on the surface erosion of the pill further
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