Computational modeling of active deformable membranes embedded in three-dimensional flows.

Abstract

Active gel theory has recently been very successful in describing biologically active materials such as actin filaments or moving bacteria in temporally fixed and simple geometries such as cubes or spheres. Here we develop a computational algorithm to compute the dynamic evolution of an arbitrarily shaped, deformable thin membrane of active material embedded in a three-dimensional flowing liquid. For this, our algorithm combines active gel theory with the classical theory of thin elastic shells. To compute the actual forces resulting from active stresses, we apply a parabolic fitting procedure to the triangulated membrane surface. Active forces are then dynamically coupled via an immersed-boundary method to the surrounding fluid whose dynamics can be solved by any standard, e.g., Lattice-Boltzmann, flow solver. We validate our algorithm using the Green's functions of Berthoumieux etal. [New J. Phys. 16, 065005 (2014)10.1088/1367-2630/16/6/065005] for an active cylindrical membrane subjected (i) to a locally increased active stress and (ii) to a homogeneous active stress. For the latter scenario, we predict in addition a nonaxisymmetric instability. We highlight the versatility of our method by analyzing the flow field inside an actively deforming cell embedded in external shear flow. Further applications may be cytoplasmic streaming or active membranes in blood flows.