Abstract
piRNAs are a class of small noncoding RNAs which are responsible for silencing the transposons in germline cells of anorganism. Recent studies depictedtheir active presence insomatic cells. In this study we have developed a approach to computationally identify the piRNA expression in neurons of aging flies, TAU mutated flies and Wild Type flies furthermore, the results evidenced differential piRNA expression i.e. 40% of piRNA expressed in TAU mutated flies, 10% were expressed in old flies, 20% were expressed in young flies and 30% expressed in wildtype flies. The expression results showedthe disregulation of piRNA in different conditions which envisage the strong role piRNA in neurogenesis, neurodegeneration and mental illness
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