Computational fluid dynamic comparison between patch-based and primary closure techniques after carotid endarterectomy

Abstract

ObjectiveThe aim of the study was to provide, by means of computational fluid dynamics, a comparative analysis after carotid endarterectomy (CEA) between patch graft (PG) and primary closure (PC) techniques performed in real carotid geometries to identify disturbed flow conditions potentially involved in the development of restenosis. MethodsEight carotid geometries in seven asymptomatic patients who underwent CEA were analyzed. In six cases (A-F), CEA was performed using PG closure; in two cases (G and H), PC was performed. Three-dimensional carotid geometries, derived from postoperative magnetic resonance angiography, were reconstructed, and a computational fluid dynamics analysis was performed. A virtual scenario with PC closure was designed in patients in whom PG was originally inserted and vice versa. This allowed us to compare for each patient hemodynamic effects in the PG and PC scenarios in terms of oscillatory shear index (OSI) and relative residence time (RRT), considered indicators of disturbed flow. ResultsFor the six original PG cases, the mean averaged-in-space OSI was 0.07 ± 0.01 for PG and 0.03 ± 0.02 for virtual-PC (difference, 0.04 ± 0.01; P = .0016). The mean of the percentage of area (%A) with OSI >0.2 resulted in 10.08% ± 3.38% for PG and 3.80% ± 3.22% for virtual-PC (difference, 6.28 ± 1.91; P = .008). For the same cases, the mean of the averaged-in-space RRT resulted in 5.48 ± 3.40 1/Pa for PG and 2.62 ± 1.12 1/Pa for virtual-PC (difference, 2.87 ± 1.46; P = .097). The mean of %A RRT >4.0 1/Pa resulted in 26.53% ± 12.98% for PG and 9.95% ± 6.53% for virtual-PC (difference, 16.58 ± 5.93; P = .025). For the two original PC cases, the averaged-in-space OSIs were 0.02 and 0.04 for PC and 0.03 and 0.02 for virtual-PG; the %A OSIs >0.2 were 0.9% and 7.6% for PC and 3.0% and 2.2% for virtual-PG; the averaged-in-space RRTs were 1.8 and 2.0 1/Pa for PC and 2.9 and 1.9 1/Pa for virtual-PG; the %A RRTs >4.0 1/Pa were 6.8% and 9.8% for PC and 9.4% and 6.2% for virtual-PG. These results revealed generally higher disturbed flows in the PG configurations with respect to the PC ones. ConclusionsOSI and RRT values were generally higher in PG cases with respect to PC, especially for high carotids or when the arteriotomy is mainly at the bulb region. Thus, an elective use of patch should be considered to prevent disturbed flows.