Computational Evidence of Altered Reward Learning in Remitted Major Depressive Disorder With a History of Psychomotor Symptoms

Abstract

Reward processing deficits are common in current and remitted major depressive disorder (rMDD). Neurobiological substrates that implement reward-based learning (e.g., corticostriatal circuitry) are also implicated in psychomotor symptoms. Thus, psychomotor symptoms may relate to greater reward-learning deficits in rMDD. The present study sought to test whether reward-based learning is altered in rMDD with, versus without past psychomotor symptoms and controls.