Computational drug repurposing: A review in modern application

Abstract

Conventional drug development are an expensive and difficult process that is time consuming, in the light of improve the traditional drug development process, drug repurposing appears as an alternative solution for this difficult process by utilizing the existing marketed drug for new drug targets. As the result of implementing this new process, by 2009 there are 30% of the newly marketed drug in U.S are the effort of repurposed drug. With the constantly growing genomic, chemical, and pathological database, computational drug repurposing are more capable of engaging into more difficult areas such as aging and outbreak. This review gives an overview of the general approaches of computational drug repurposing, showcasing works that demonstrated the realistic application of this innovative process. Lastly, it concludes the limitations that still needs to be improved up on this process.