Abstract
Insulin resistance syndrome is a major risk factor for atherosclerosis and coronary heart disease (CAD). Endothelial dysfunction due to reduced nitric oxide generation is seen in both insulin resistance syndrome and CAD. Endothelial dysfunction also occurs in obesity, diabetes mellitus, and other cardiovascular diseases. In the present study, we employed multiple sequence alignment using Clustal W tool and constructed a phylogenetic tree using functional protein sequences extracted from NCBI and Gene cards. These studies showed that nitric oxide synthase and adiponectin play a major role in insulin resistance and coronary artery disease. This and other studies suggest that endothelial dysfunction is an early event in insulin resistance syndrome.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
