Computational Approaches in Tissue Engineering

Abstract

Scaffolds designed with intricate and controlled interior architecture represent a challenging problem for tissue engineering. Various scaffold-fabricating techniques allow the creation of complex micro-structure but with irregular pore characteristics, resulting in inappropriate & asymmetrical structures not suitable for tissue engineering applications. Computer-Aided Tissue Engineering (CATE) integrates advanced technologies from Biology, Information Science and Engineering for Tissue Engineering applications. In particulars, computer-aided design (CAD), medical image processing, computer-aided manufacturing (CAM), and solid freeform fabrication (SFF) are employed for simulation, design and manufacturing of tissue scaffolds with controlled and regular pore architecture. CATE application to the design and fabrication of scaffolds can guide to improve the biomimetic and biological features of the scaffolds. This paper aims to understand the principles behind various computer aided approaches being utilized for tissue engineering applications particularly cell-scaffold implant modeling, designing and manufacturing.