Abstract
The superhelical strain in a closed circular B DNA molecule may be relieved at the cost of local conformational transitions to non-B forms wherever possible. Some of these transitions, such as the supercoil-induced B-Z transition in a short purine-pyrimidine stretch, are known to be highly cooperative and can be described in terms of a two-state approximation for the relevant chain partition function. How the presence of DNA-binding ligands may affect such transitions within the supercoiled molecule has been analysed. The result of a preliminary investigation into the effect of sharp bends in the supercoiled DNA structure is also reported.
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