Abstract
Choroidal neovascularization (CNV) is a severe eye disease that leads to blindness, especially in the elderly population. Various endogenous and exogenous regulatory factors promote its pathogenesis. However, the detailed molecular biological mechanisms of CNV have not been fully revealed. In this study, by using advanced computational tools, a number of key gene ontology (GO) terms and KEGG pathways were selected for CNV. A total of 29 validated genes associated with CNV and 17,639 nonvalidated genes were encoded based on the features derived from the GO terms and KEGG pathways by using the enrichment theory. The widely accepted feature selection method—maximum relevance and minimum redundancy (mRMR)—was applied to analyze and rank the features. An extensive literature review for the top 45 ranking features was conducted to confirm their close associations with CNV. Identifying the molecular biological mechanisms of CNV as described by the GO terms and KEGG pathways may contribute to improving the understanding of the pathogenesis of CNV.
Highlights
Choroidal neovascularization (CNV) is a serious eye disease involving the abnormal growth of blood vessels in the choroid region [1,2,3]
Age-related macular degeneration (ARMD), myopia, and presumed ocular histoplasmosis syndrome (POHS) are the three major pathogeneses attributed to CNV [6,7,8]
By applying the maximum relevance criterion, all the features were ranked by their relevance to the target variables, and the rank of a corresponding feature in the output MaxRel feature list for a gene ontology (GO) term or KEGG pathway indicated its association with CNV
Summary
Choroidal neovascularization (CNV) is a serious eye disease involving the abnormal growth of blood vessels in the choroid region [1,2,3]. CNV is a major cause of pathological visual loss in aging populations [5]. Given that ARMD is the most common cause of visual loss in people older than 50 years, CNV is speculated to be directly linked to such pathological visual loss. Aside from ARMD, the other two pathological processes—myopia [10] and POHS [11]—are linked to pathological visual loss. This finding validates the specific role of CNV in pathological visual loss
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