Abstract
Thyroid cancer is one of the major cancers around the world. In this study the whole thyroid genome is systematically scanned in order to hit those molecular targets which are highly associated with thyroid cancer. To achieve this goal bioinformatics methodologies are combined. These include the high throughput microarray analysis combined with Serial analysis of gene expression. The results obtained revealed Glycoprotein M6A (GPM6A) as a novel associated gene marker. It belongs to the glycoprotein’s family which plays a major role in cell migration and also known as the major contributors in tumor formation. Moreover the biological pathway of GPM6A is not yet been defined. In this study by assessing the whole biological mechanism the pathway is also inferred .This new drug target will help the biologists in finding the early diagnosis and better treatment for the thyroid cancer patients.
Highlights
Cancer affects people at all ages with the hazard for most types increasing with age
Clustering parameters: All of the three clustering means unravel the presence of Glycoprotein M6A (GPM6A) as novel contributor of papillary thyroid carcinoma (PTC) and a negative significant gene as it shown down regulation behavior clearly highlighted in figures 3, 4, 5 and 6
Along with that the biological signaling pathway of GPM6A was predicted in this study shown in figure 7
Summary
Cancer affects people at all ages with the hazard for most types increasing with age. The proportion of deaths from cancer is expected to rise worldwide [1]. In order to comprehend the biology of cancer it’s necessary to dig out the genes which serves as oncogenes. Gene expression analysis is the most gifted field in mining the diseased genes as it provides both the experimental as well as in silico means for screening cancer related genes. Glycoprotein M6A is expressed in neuronal membrane proteins as well as in non-neuronal, but is found to be mainly expressed in neuronal membranes as a stress responsive gene. Stress has an important effect on thyroid autoimmunity. Stress targets endocrine glands including thyroid and lessen the immunity in the body which causes many thyroid diseases [2]
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