COMPUTATIONAL ANALYSIS OF TRANSCRIPTION FACTORS AS CANCER DRUG TARGETS WITH POTENTIAL INHIBITORS FROM THE NPACT DATABASE

Abstract

Transcription factors have proven to be promising targets for the treatment of cancer. Transcription factors are involved in the production of oxygen. External cervical events are initiated by receptors, such as cytotoxic exposures or cytokine receptors that trigger signalling cascades that activate transcription factors. Transcriptional factors are known to be highly active in most human cancer cells, making them suitable for the study and development of anticancer therapies. Three transcription factors were investigated as potential targets in this study. Analysis of string interactions reveals their interaction network. DNA-TF binding was followed by docking with 96 natural compounds to the DNA binding pocket of the transcription factor. Using post-docking processing, compounds were ranked according to their binding energy, hydrogen bond number, and dissociation constant; Withanolide D targeted more than one transcription factor. Therefore, the compound is suitable for in vitro testing using different cancer cell lines.