Computational Analysis of the Structural Composition of Coronavirus Genomes

Abstract

Ecological disasters , wars in regions with microbiological weapons depots , deforestation , domestication of wild animals , consumption of infected animals , contamination of water and food products and their components , experiments with viruses , deficiencies and other defects of the immune system in modern humans and other mammals became the impetus for the evolution of new dangerous and extremely dangerous viruses . Due to the emergence of new dangerous viruses , the importance and demand for knowledge and skills o f c omputational biology , e pidemiology a nd v irology i n m odern s ociety h ave i ncreased . Modern s equencers a re c apable o f p roducing l arge a mounts o f b ioinformatic d ata t hat i s r epresented i n t he f orm o f g enomic t exts . C omparative с omputational a nalysis o f t his i nformation i s n ecessary t o c larify t he i ssues o f p hylogenesis , m utational p rofiling , m olecular e volution , i dentification o f i nsertions o f o ther g enomes , a nnotation o f g enome r egions , s earch f or t argets f or v accine d evelopment a nd p harmacotherapy . In t his с ontext , a uthors c onducted a c omputational e xperiment o f c omparative a nalysis o f t he g enomic t exts o f B elarusian coronavirus s amples a gainst a n umber o f s elected c omplete g enomes o f d angerous a nd e xtremely d angerous v iruses a nd c oronaviruses o f v arious o rigins . Data a nalysis w as p erformed u sing t he YASS, g enomic t exts w ere d ownloaded f rom t he GISAID, t he c ustom g enomic d ata p rocessing p ipeline b ased o n t he Galaxy b ioinformatics p latform w as a lso a pplied . The a rticle p resents t he r esults o f a n a nalysis o f t he a vailable s cientific l iterature a nd t he c omputational e xperiment c omparing t he g enomic t exts o f B elarusian coronavirus s amples w ith a n umber o f s elected c omplete g enomes o f d angerous a nd e specially d angerous v iruses a nd c oronaviruses o f v arious o rigin . A s ignificant s imilarity o f t he n ew coronavirus w ith t he r ecombinant coronavirus, a s w ell a s p artial s imilarity w ith s ynthetic coronavirus, R ubella , E bola 1976, HIV-2 ( h uman i mmunodeficiency v irus ) , Middle East r espiratory s yndrome , s imian i mmunodeficiency a nd M arburg f ever v iruses h ave b een f ound .