Computation of Energy, Intensity and Thermodynamic Parameters for the Interaction of Ln(III) with Nucleic Acid: Analysis of Structural Conformations, Chemical Kinetics and Thermodynamic Behaviour through 4f-4f Transition Spectra as Probe

N Bendangsenla,Juliana Sanchu,M Indira Devi,T Moainla

doi:10.4236/msce.2018.67018

N Bendangsenla, Juliana Sanchu + Show 2 more

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https://doi.org/10.4236/msce.2018.67018

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Abstract

Nucleosides and Nucleotides are polydentate ligands, offering potential binding sites for metal ions. Energy interaction parameters: Slater Condon Fk (cm-1), Spin Orbit interaction ξ4f (cm-1), Nephelauxetic Ratio (β), Bonding (b1/2) and Covalency (δ) parameter for the interaction of Pr(III) with Nucleoside and Nucleotide are evaluated to study the mode of binding of the Nucleic Acid Components (Guanosine and Guanosine Triphosphate) with Pr(III). Further Intensity Parameters like Oscillation Strength and Judd Ofelt Parameter (T2, T4, T6) have been evaluated to investigate degree of inner or outer sphere co-ordination of Pr(III) with Nucliec Acid ligands. Comperative Absorption Spectra in different solvents substantiate the informations, gathered from the evaluated values of both energy interaction and intensity parameters. Further evaluation of Thermodynamic parameters (ΔG, ΔH and ΔS) through Kinetic studies enable to provide the detailed information about the reaction pathways and thermodynamic behavour of the complexation process of neucleosides and nucleotides with Pr(III) and Ca2+.

Highlights

Energy interaction parameters: Slater Condon Fk, Spin Orbit interaction ξ4 f, Nephelauxetic Ratio (β), Bonding (b1⁄2) and Co-valency (δ) parameter for the interaction of Pr(III) with Nucleoside and Nucleotide are evaluated to study the mode of binding of the Nucleic Acid Components (Guanosine and Guanosine Triphosphate) with Pr(III)
Further evaluation of Thermodynamic parameters (ΔG, ΔH and ΔS) through Kinetic studies enable to provide the detailed information about the reaction pathways and thermodynamic behavour of the complexation process of neucleosides and nucleotides with Pr(III) and Ca2+
Because of their remarkable and unmatched optical, spectroscopic, luminescent and magnetic properties, the lanthanides are under the limelight when it comes to high technology

Summary

Introduction

Because of their remarkable and unmatched optical, spectroscopic, luminescent and magnetic properties, the lanthanides are under the limelight when it comes to high technology. Solution spectral studies through kinetic and thermodynamic approach involving lanthanide complexes are very pertinent information about the mechanism, reaction pathways, and about the chemical bonding and conformations. Solution spectral studies through kinetic approach involving lanthanide complexes are very important because it can provide very pertinent information about the mechanism, reaction pathways, and about the chemical bonding and conformations. Quantitative Absorption Spectroscopy can prove as an improved tool on mechanistic, diagnostic and condensation studies too [14] In this Paper we will use comparative absorption and absorption difference spectrophotometry involving 4f-4f transition spectra as probe in understanding the binding characteristics of Guanosine and GTP with lanthanides (Pr3+) in the presence and absence of Ca2+; it will be further studied through kinetic and thermodynamic approach

Methodology

Methods for Chemical Kinetic Studies

Results and Discussions

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