Compromised order processing in Alzheimer's dementia demonstrated by cortical thickness, DTI and rsfMRI

Abstract

Event Abstract Back to Event Compromised order processing in Alzheimer's dementia demonstrated by cortical thickness, DTI and rsfMRI Maya De Belder1*, Jean-Philippe Van Dijck1, Hannelore Aerts1, Patrick Santens2, Anne Sieben2, Fabrizio Doricchi3 and Wim Fias1 1 Ghent University, Belgium 2 Ghent University Hospital, Belgium 3 Sapienza University of Rome, Italy Executive dysfunction observed in patients with Alzheimer’s dementia is commonly attributed to higher order working memory (WM) processes. The mental representation of serial order is one of the essential components represented in serial verbal WM and is crucial for smooth daily life functioning (e.g., cooking, memorising a phone number). It remains unclear to what extent these serial constructions are affected in Alzheimer’s dementia and which brain structures are essentially involved to successfully represent order. The data of 18 patients diagnosed with Alzheimer’s dementia and 13 healthy elderly controls was collected. They were submitted to a neuropsychological test battery, having to perform a Backward Digit Span (BDS) task, Forward Digit span (FDS) and Corsi Block (CB) test, from which an order-measure was calculated to investigate order-specific regional alterations in the brain. The order-measure was associated with following subjects’ brain data; anatomical information by T1, white matter integrity using the fractional anisotropy (FA) maps of diffusion tensor images and connectivity measures derived from resting state networks. Overall, the results of the analyses revealed the affected brain structures demonstrating the order-specific representational problems observed in Alzheimer’s. More specifically, order-problems within WM are associated with specific alterations in the brain; mainly localised in frontal and parietal regions, fronto-parietal and fronto-temporal white matter tracts Keywords: Alzheimer Disease, working memory, serial order, DTI, RsfMRI, cortical thickness Conference: 12th National Congress of the Belgian Society for Neuroscience, Gent, Belgium, 22 May - 22 May, 2017. Presentation Type: Poster Presentation Topic: Disorders of the Nervous System Citation: De Belder M, Van Dijck J, Aerts H, Santens P, Sieben A, Doricchi F and Fias W (2019). Compromised order processing in Alzheimer's dementia demonstrated by cortical thickness, DTI and rsfMRI. Front. Neurosci. Conference Abstract: 12th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2017.94.00113 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 18 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Mrs. Maya De Belder, Ghent University, Ghent, Belgium, maya.debelder@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Maya De Belder Jean-Philippe Van Dijck Hannelore Aerts Patrick Santens Anne Sieben Fabrizio Doricchi Wim Fias Google Maya De Belder Jean-Philippe Van Dijck Hannelore Aerts Patrick Santens Anne Sieben Fabrizio Doricchi Wim Fias Google Scholar Maya De Belder Jean-Philippe Van Dijck Hannelore Aerts Patrick Santens Anne Sieben Fabrizio Doricchi Wim Fias PubMed Maya De Belder Jean-Philippe Van Dijck Hannelore Aerts Patrick Santens Anne Sieben Fabrizio Doricchi Wim Fias Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.