Abstract
ObjectivesTo compare volumetric and functional parameters of the atria derived from highly accelerated compressed sensing (CS)–based cine sequences in comparison to conventional (Conv) cine imaging.MethodsCS and Conv cine sequences were acquired in 101 subjects (82 healthy volunteers (HV) and 19 patients with heart failure with reduced ejection fraction (HFrEF)) using a 3T MR scanner in this single-center study. Time-volume analysis of the left (LA) and right atria (RA) were performed in both sequences to evaluate atrial volumes and function (total, passive, and active emptying fraction). Inter-sequence and inter- and intra-reader agreement were analyzed using correlation, intraclass correlation (ICC), and Bland-Altman analysis.ResultsCS-based cine imaging led to a 69% reduction of acquisition time. There was significant difference in atrial parameters between CS and Conv cine, e.g., LA minimal volume (LAVmin) (Conv 24.0 ml (16.7–32.7), CS 25.7 ml (19.2–35.2), p < 0.0001) or passive emptying fraction (PEF) (Conv 53.9% (46.7–58.4), CS 49.0% (42.0–54.1), p < 0.0001). However, there was high correlation between the techniques, yielding good to excellent ICC (0.76–0.99) and small mean of differences in Bland-Altman analysis (e.g. LAVmin − 2.0 ml, PEF 3.3%). Measurements showed high inter- (ICC > 0.958) and intra-rater (ICC > 0.934) agreement for both techniques. CS-based parameters (PEF AUC = 0.965, LAVmin AUC = 0.864) showed equivalent diagnostic ability compared to Conv cine imaging (PEF AUC = 0.989, LAVmin AUC = 0.859) to differentiate between HV and HFrEF.ConclusionAtrial volumetric and functional evaluation using CS cine imaging is feasible with relevant reduction of acquisition time, therefore strengthening the role of CS in clinical CMR for atrial imaging.Key Points• Reliable assessment of atrial volumes and function based on compressed sensing cine imaging is feasible.• Compressed sensing reduces scan time and has the potential to overcome obstacles of conventional cine imaging.• No significant differences for subjective image quality, inter- and intra-rater agreement, and ability to differentiate healthy volunteers and heart failure patients were detected between conventional and compressed sensing cine imaging.
Highlights
Left and right ventricular volumes and function are important indicators for the severity of cardiac diseases, and cardiac magnetic resonance imaging (CMR) is considered reference standard for volumetric assessment [1]
compressed sensing (CS) and Conv cine sequences were acquired in 101 subjects (82 healthy volunteers (HV) and 19 patients with heart failure with reduced ejection fraction (HFrEF)) using a 3T MR scanner in this single-center study
Atrial volumetric and functional evaluation using CS cine imaging is feasible with relevant reduction of acquisition time, strengthening the role of CS in clinical CMR for atrial imaging
Summary
Left and right ventricular volumes and function are important indicators for the severity of cardiac diseases, and cardiac magnetic resonance imaging (CMR) is considered reference standard for volumetric assessment [1]. Conventional cine imaging (a) can be prone to artifacts due to irregular heartbeats and (b) is time-consuming as several heartbeats are needed to gather all required data [21] Such limitations have recently been addressed by highly accelerated acquisition techniques, such as compressed sensing (CS) by reducing the number of required heartbeats to gain all needed information. The purpose of this study was to evaluate the agreement in atrial volumes and function between CS-based and conventional cine imaging in HFrEF patients and healthy volunteers (HVs). We evaluated the impact of CS on interand intra-reader agreement and investigated if there are differences between both cine sequences in the ability to discriminate healthy volunteers from HFrEF patients
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