Abstract
In the present work the temperature dependence of heat capacity for methylprednisolone has been measured for the first time over the temperature range from 6 to 350K using by precision adiabatic vacuum calorimetry. Based on the experimental data, the thermodynamic functions of the methylprednisolone, namely, the heat capacity, enthalpy H°(T)−H°(0), entropy S°(T)−S°(0) and Gibbs function G°(T)−H°(0) have been evaluated from the experimental values for the range from T→0 to 350K. Standard molar enthalpy of combustion (−11898.9±6.7)kJ·mol−1 of the methylprednisolone was measured for the first time using high-precision combustion calorimeter. The standard molar enthalpy of formation in the crystalline state (−1045.8±7.3)kJ·mol−1 of compound at 298.15K was derived from the combustion experiments. The standard molar enthalpy of sublimation at 298.15K (194.5±2.2)kJ·mol−1 was measured by using the quartz-crystal microbalance (QCM). Using combination of the adiabatic and combustion calorimetry with the result from QCM, the thermodynamic functions of the methylprednisolone at T=298.15K and p=0.1MPa have been calculated.
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