Comprehensive Review on Effectiveness of Single and Multiple Visit Regenerative Endodontics and Comparative Evaluation of Patient Reported Outcomes in Single Visit and Multiple Visit Regenerative Endodontics in Permanent Teeth: A Systematic Review and Meta-Analysis

Abstract

This systematic review aimed to investigate the efficacy of single visit and multiple visit regenerative endodontics and compare the patient based clinical outcome of permanent teeth treated with single visit & multiple visit regenerative endodontic therapy. The protocol was registered with Prospero registration code CRD42024505225. A comprehensive search strategy was performed in different databases—PubMed, CENTRAL, ScienceDirect, CINAHL, ERIC and PsycINFO using searching keywords and was limited to studies published till January 2024 in English. The Inclusion criteria for the study were randomized clinical trial, prospective clinical studies, case Reports and case Series. The search found 20 eligible articles, which were included in the study. Risk of bias of clinical studies was conducted using ROBINS-I tool and JBL tool was used for quality assessment of case reports and case series included. The conclusions of our study concluded that in terms of clinical outcome both the approaches presented success of treatment with odds were greater with multiple visits as compared to single visit REP but statistically there was no difference between both the group. Radiographically outcome - In terms of root width diameter post treatment, single visit REPs were more successful as compared to multiple visits but statistical difference was not present. However, further research and emphasis should be given on undertaking more clinical trials regeneration in endodontics to provide proper results.