Comprehensive review of current trends in adenocarcinoma of gall bladder in northern Indian region: An imperative clinico-histological approach

Abstract

We are aware that epidemiological studies have established significant geographical and ethnic differences and this disproportionality is quite high in Southeast Asia, but the numbers are few in the America and other parts of world. Age, female gender, congenital biliary tract abnormalities and genetic predisposition represent imperative irreversible risk factors. Environment factors too have been implicated in causing gallbladder carcinoma. Other causes of gall bladder carcinoma include bile duct cholelithiasis, chronic inflammatory conditions and parasite infestation. These occurrences are associated with high mortality rates. Countries with highest gallstone prevalence usually suffer with greatest gallbladder cancer mortality. Indistinct and unclear clinical signs frequently prolong the gallbladder cancer diagnosis and lead to its eventual development and poor prognosis. Therefore, surgery seems to be viable treatment option which is practiced all around the globe since decades. Some patients are lucky to have gallbladder cancer treated incidentally when cholecystectomy is performed for cholelithiasis. This review is an attempt to genuinely explore the current trends in adenocarcinoma of gall bladder in Northern Indian region by clinico-histological approach.