Abstract
Qing-Fei-Pai-Du decoction (QFPDD) is a Chinese medicine compound formula recommended for combating corona virus disease 2019 (COVID-19) by National Health Commission of the People's Republic of China. The latest clinical study showed that early treatment with QFPDD was associated with favorable outcomes for patient recovery, viral shedding, hospital stay, and course of the disease. However, the effective constituents of QFPDD remain unclear. In this study, an UHPLC-Q-Orbitrap HRMS based method was developed to identify the chemical constituents in QFPDD and the absorbed prototypes as well as the metabolites in mice serum and tissues following oral administration of QFPDD. A total of 405 chemicals, including 40 kinds of alkaloids, 162 kinds of flavonoids, 44 kinds of organic acids, 71 kinds of triterpene saponins and 88 kinds of other compounds in the water extract of QFPDD were tentatively identified via comparison with the retention times and MS/MS spectra of the standards or refereed by literature. With the help of the standards and in vitro metabolites, 195 chemical components (including 104 prototypes and 91 metabolites) were identified in mice serum after oral administration of QFPDD. In addition, 165, 177, 112, 120, 44, 53 constituents were identified in the lung, liver, heart, kidney, brain, and spleen of QFPDD-treated mice, respectively. These findings provided key information and guidance for further investigation on the pharmacologically active substances and clinical applications of QFPDD.
Highlights
Qingfei Paidu decoction (QFPDD) is a Chinese medicine compound formula recommended for combating corona virus disease 2019 (COVID-19) by National Health Commission of the People's Republic of China
An UHPLC-Q-Orbitrap HRMS based method was established for chemical profiling the constituents in QFPDD, while the absorbed prototypes and metabolites occurring in mice serum and tissues were investigated following oral administration of QFPDD
These findings provided key information and guidance for further investigation on the pharmacologically active substances and clinical applications of QFPDD
Summary
Qingfei Paidu decoction (QFPDD) is a Chinese medicine compound formula recommended for combating corona virus disease 2019 (COVID-19) by National Health Commission of the People's Republic of China. In China, several Chinese medicine compound formulas, such as Qingfei Paidu decoction (QFPDD), Jingyin granules and Lianhua Qingwen capsule, have been validated playing an active role in combating this epidemic, especially alleviating the symptoms of some moderate and mild patients [7]. Among all recommend Chinese medicines for combating COVID19 in China, QFPDD has drawn much attention owing to its effectiveness of COVID-19. As the first Chinese medicine compound formula recommended by National Health Commission of the People's Republic of China for combating COVID-19, QFPDD has been used to treat thousands of COVID-19 patients with the total effective rate of 97% [8,9,10]. Early treatment with QFPDD may serve as an effective strategy in controlling the epidemic [12]
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