Comprehensive investigation on fabrication, spectral characterization and biological importance of Co(II) and Ni(II) heteroleptic complexes

Abstract

Using the microwave irradiation approach, novel metallic complexes of Cobalt [Co(II)] and Nickel [Ni(II)] complexes of 2-aminothiazole (ATZ) and thiocyanate ligands [IUPAC Name: Di(2-aminothiazole) thiocyanato cobalt(II), Di(2-aminothiazole) thiocyanato nickel(II)] were created. The molecular formulas and the geometry of the complexes have been deduced by elemental analysis, molar conductance, magnetic moment, UV–visible, FT-IR, thermogravimetric analysis, cyclic voltammetry, and powder-XRD techniques. Molar conductance values indicate that the complexes are non-electrolyte (1:0) type. The complexes have octahedral structure is revealed by the magnetic moment and UV–visible spectra. The FT-IR spectra reveal that the 2-aminothiazole and thiocyanate ions are coordinated to the metal ion in a monodentate manner. The antibacterial capabilities of ligands and their Co(II) and Ni(II) compounds were studied against a restricted set of microorganisms utilizing the agar-well diffusion method and varying concentrations.When compared to free 2-aminothiazole ligand, the complexes exhibit possible activity against the fungus than bacteria. By assessing how well the complexes and ligands interact with the stable free radical DPPH, their ability to scavenge free radicals has been established. Comparing the complexes to the free ligand, the complexes exhibit greater antioxidant activity due to the fact that metal complexes are widely recognized for their capacity to accelerate medication action and boost therapeutic agent potency when they coordinate with a metal ion. The primary goal of this research is to develop multimodal medicinal drugs, which include studying the roles of 2-aminothiazole and its transition metal complexes.