Abstract
Introduction: Diastolic dysfunction is a contributing factor in most cardiovascular diseases. For example, from the ischemic cascade, it is well known that ventricular relaxation is impaired prior to changes in systolic function. Diastolic parameters are predictive of outcome in acute MI, and a third to a half of all cases of heart failure have preserved LVEF (>50%). The importance of diastolic dysfunction in the many manifestations of heart failure is not well characterized. Clinical evaluation of diastolic function is predominantly by echocardiography, for which several conventional and novel quantitative measures of function are available, the vast majority of which are not routinely acquired using MRI. With its increasing use in the clinic and with improvements in temporal resolution it is now practical for MRI to provide an equivalent or superior assessment of diastolic function. We illustrate the measurement of conventional and novel diastolic parameters using universally available clinical pulse sequences in healthy controls and a population of heart failure patients.
Highlights
Prophylactic implantation of a cardioverter/ defibrillator (ICD) has been shown to reduce mortality in patients with chronic myocardial infarction (CMI) and an increased risk for life threatening ventricular arrhythmia (VA)
The purpose of this study was to demonstrate a novel approach to imaging the vessel wall and vessel wall calcification using susceptibility weighted imaging [2] (SWI) with no need to suppress the signal from the blood
Optimizing the imaging parameters: The SWI sequence parameters were optimized to allow for the best visualization of the femoral artery lumen in the magnitude images and the arterial wall in the phase images
Summary
Prophylactic implantation of a cardioverter/ defibrillator (ICD) has been shown to reduce mortality in patients with chronic myocardial infarction (CMI) and an increased risk for life threatening ventricular arrhythmia (VA). Methods: In 11 patients (age 0.7 – 27 years) with complex congenital heart disease, surgical questions were directed towards palliative or corrective surgery but consensus about the optimum treatment strategy was not reached using standard diagnostic tools including echocardiography, catheterization and conventional magnetic resonance imaging (MRI). In these patients, three-dimensional printed cast and virtual computer models of the heart were made on the basis of high-resolution whole-heart and/or cineMRI.
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