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Abstract
BackgroundInfectious diseases are major public health problem. It is increasingly affecting more than 50 million people worldwide. Targeting shikimate pathway could be efficiently used for the development of broad spectrum antimicrobial compound against variety of infectious diseases. Chorismate synthase is an enzyme in shikimate pathway that catalyzes Phosphoenol pyruvate to chorismate in most of the prokaryotic bacteria. This step is crucial for its growth, since Chorismate acts as a precursor molecule for the synthesis of aromatic amino acids. Hence, we present a comprehensive database of Chorismate Synthase Database (CSDB) which is a manually curated database. It provides information on the sequence, structure and biological activity of chorismate synthase from shikimate pathway of pathogenic bacteria. Design of suitable inhibitors for this enzyme, hence could be a probable solution to destroy its proteomic machinery and thereby inhibit the bacterial growth.DescriptionThe aim of this study was to characterise chorismate synthase enzyme belonging to pathogenic bacteria to analysis the functional and structural characterization of chorismate synthase is very important for both structure-based and ligand based drug design.ConclusionsThe broad range of data easy to use user interface makes csdb.in a useful database for researchers in designing drugs.
Highlights
Infectious diseases are major public health problem
Targeting the seven enzymes of shikimate pathway could be an effective target for the development of antimicrobial and herbicidal compounds as it is a crucial pathway for synthesis of aromatic amino acid in bacteria and plants but not in mammals [2,3,4,5,6,7]
The monofunctional form of chorismate synthase is found in plants and bacteria whereas in bifunctional it occurs in fungi [3]
Summary
Infectious diseases are major public health problem. It is increasingly affecting more than 50 million people worldwide. Chorismate synthase is an enzyme in shikimate pathway that catalyzes Phosphoenol pyruvate to chorismate in most of the prokaryotic bacteria This step is crucial for its growth, since Chorismate acts as a precursor molecule for the synthesis of aromatic amino acids. We present a comprehensive database of Chorismate Synthase Database (CSDB) which is a manually curated database It provides information on the sequence, structure and biological activity of chorismate synthase from shikimate pathway of pathogenic bacteria. Chorismate synthase (CS) catalyzes conversion of 5- enolpyruvylshikimate 3-phosphate (EPSP) to chorismate, is the final step of shikimate pathway [3,8] It is an essential precursor for the synthesis of p-aminobenzoic acid and folate [9]. The monofunctional form of chorismate synthase is found in plants and bacteria whereas in bifunctional it occurs in fungi [3]
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